Scientists found why lithium is effective at treating bipolar.

So Scientists found out why lithium is effective at treating bipolar, with could lead to better meds with fewer side-effects.

So as we know bipolar caused extreme change in a person mood.

The extreme change in mood in bipolar have been strongly associated with disruptions in circadian rhythms our body clock.

A study shown a potent effect of lithium in increasing the strength of the clock rhythms, showing a link between the mood-stabilizer, bipolar, and body clocks.

By tracking a key clock protein they discovered that lithium increased the strength of the clockwork in cells by up to three-fold by blocking a enzyme called glycogen synthase kinase or GSK3.

This will open the opportunities to develop new drugs for bipolar that mimic and enhance the effect lithium has on GSK3 without the side-effects lithium have which include nausea, acne, thirstiness, muscle weakness, tremor, sedation and/or confusion.

Our study has identified the robust rhythm-enhancing effect of GSK3 inhibition, which has potential to be developed as a new pharmacological approach to regulate body clocks, and there may also be beneficial effects leading to new treatments for bipolar disorder.

http://www.manchester.ac.uk/discover/news/article/?id=8058

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People with bipolar are risk-takers.

Researchers at the Universities of Manchester and Liverpool have found that the circuits in the brain involved in pursuing and relishing rewarding experiences are more strongly activated in people with bipolar disorder -- guiding them towards riskier gambles and away from safer ones.

Faulty Body Clock Genes May Be Responsible for Bipolar

Sorry for the long wait hear my new post after all this wait.

So a malfunctioning circadian clock genes may be responsible for bipolar.

Researchers writing in the open access journal BMC Psychiatry found four versions of a regulatory gene RORB that were associated with bipolar.